Breast cancer h-31

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Bone is one of the most common sites of metastasis in breast cancer. For metastasis to occur in bone, tumor cells must induce osteolysis by osteoclasts. Degradation of the osteoid layer by type I collagenase is a necessary process before osteolysis can occur because the psteoid layer hinders osteoclasts from adhering to bone.

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Bone is one of the most common sites of metastasis in breast cancer. For metastasis to occur in bone, tumor cells must induce osteolysis by osteoclasts. Degradation of the osteoid layer by type I collagenase is a necessary process before osteolysis can occur because the osteoid layer hinders osteoclasts from adhering to bone.

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Study record managers: refer to the Data Element Definitions if submitting registration or results information. RATIONALE: Drugs used in chemotherapy, such as doxorubicin, cyclophosphamide, and paclitaxel, use different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies such as trastuzumab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.

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While ER itself is a predictor of response to such therapies, there exists a need to find more biomarkers and novel targets to treat resistant tumors. Historically, breast cancer was classified on the basis of histopathology but with the advent of techniques such as microarray analysis, molecular sub-types were defined 2. Breast cancers that lack the expression of all 3 receptors are classified as triple negative breast cancers TNBCs.

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Impact factor 8. Nanotheranostics ; 3 4 : International Journal of Biological Sciences.

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Metrics details. The long time from exposure to potentially harmful chemicals until breast cancer occurrence poses challenges for designing etiologic studies and for implementing successful prevention programs. Growing evidence from animal and human studies indicates that distinct time periods of heightened susceptibility to endocrine disruptors exist throughout the life course.

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Breast cancer is cancer that develops from breast tissue. Risk factors for developing breast cancer include being female, obesitylack of physical exercise, drinking alcoholhormone replacement therapy during menopauseionizing radiationearly age at first menstruationhaving children late or not at all, older age, prior history of breast cancer, and family history. The balance of benefits versus harms of breast cancer screening is controversial. A Cochrane review stated that it is unclear if mammographic screening does more good or harm.

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